Pigs with δ-sarcoglycan deficiency exhibit traits of genetic cardiomyopathy.
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ABSTRACT:
SUBMITTER: Matsunari H
PROVIDER: S-EPMC7280178 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
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Pigs with δ-sarcoglycan deficiency exhibit traits of genetic cardiomyopathy.
Matsunari Hitomi H Honda Michiyo M Watanabe Masahito M Fukushima Satsuki S Suzuki Kouta K Miyagawa Shigeru S Nakano Kazuaki K Umeyama Kazuhiro K Uchikura Ayuko A Okamoto Kazutoshi K Nagaya Masaki M Toyo-Oka Teruhiko T Sawa Yoshiki Y Nagashima Hiroshi H
Laboratory investigation; a journal of technical methods and pathology 20200214 6
Genetic cardiomyopathy is a group of intractable cardiovascular disorders involving heterogeneous genetic contribution. This heterogeneity has hindered the development of life-saving therapies for this serious disease. Genetic mutations in dystrophin and its associated glycoproteins cause cardiomuscular dysfunction. Large animal models incorporating these genetic defects are crucial for developing effective medical treatments, such as tissue regeneration and gene therapy. In the present study, w ...[more]
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