Establishment of a guided, in vivo, multi-channel, abdominal, tissue imaging approach.

ABSTRACT: Novel tools in humane animal research should benefit the animal as well as the experimentally obtained data. Imaging technologies have proven to be versatile and also in accordance with the demands of the 3 R principle. However, most imaging technologies are either limited by the target organs, number of repetitive imaging sessions, or the maximal resolution. We present a technique-, which enables multicolor abdominal imaging on a tissue level. It is based on a small imaging fiber endoscope, which is guided by a second commercial endoscope. The imaging fiber endoscope allows the distinction of four different fluorescence channels. It has a size of less than 1 mm and can approximately resolve single cells. The imaging fiber was successfully tested on cells in vitro, excised organ tissue, an

SUBMITTER: Bahlmann J 

PROVIDER: S-EPMC7280182 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature