Ensilicated tetanus antigen retains immunogenicity: in vivo study and time-resolved SAXS characterization.

ABSTRACT: Our recently developed ensilication approach can physically stabilize proteins in silica without use of a pre-formed particle matrix. Stabilisation is done by tailor fitting individual proteins with a silica coat using a modified sol-gel process. Biopharmaceuticals, e.g. liquid-formulated vaccines with adjuvants, frequently have poor thermal stability; heating and/or freezing impairs their potency. As a result, there is an increase in the prevalence of vaccine-preventable diseases in low-income countries even when there are means to combat them. One of the root causes lies in the problematic vaccine 'cold chain' distribution. We believe that ensilication can improve vaccine availability by enabling transportation without refrigeration. Here, we show that ensilication stabilizes tetanus tox

SUBMITTER: Doekhie A 

PROVIDER: S-EPMC7280242 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature