Low bone mineral density is associated with hypogonadism and cranial irradiation in male childhood cancer survivors.

ABSTRACT: We investigated if bone mineral density was related to testosterone deficiency and/or previous cancer treatment in men who were childhood cancer survivors. Men with untreated testosterone deficiency or previous treatment with cranial irradiation were at increased risk of impaired bone health. Prevention of osteoporosis should be considered in their follow-up.

Introduction

Childhood cancer survivors (CCS) are at increased risk of hypogonadism. Reduced bone mineral density (BMD) has been reported in CCS but it is unclear whether this is due to hypogonadism or a direct effect of cancer therapy. This study investigated BMD in CCS, and association with hypogonadism, previous treatment and cancer type.

Methods

Investigation of 125 CCS (median age 33.7 at inclusion; 9.6 at diagnosis

SUBMITTER: Isaksson S 

PROVIDER: S-EPMC7280350 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature