The Accuracy of Cardiovascular Pooled Cohort Risk Estimates in U.S. Older Adults.

ABSTRACT:

Background

The ACC/AHA guidelines for primary prevention rely on the Pooled Cohort Risk Equations (PCE) risk estimates of atherosclerotic cardiovascular disease (ASCVD) to guide treatment decisions. In light of the PCE being derived in younger populations, their accuracy in older adults is uncertain.

Objective

To evaluate the predictive accuracy and calibration of the PCE in older individuals.

Design and setting

We estimated CVD predicted and observed risk among individuals from four large prospective cohort studies: Cardiovascular Health Study, Multiethnic Study of Atherosclerosis, Framingham Original, and Framingham Offspring.

Participants

12,527 overall individuals without ASCVD, including 9864 individuals aged 40-74 years and 2663 aged ≥75 years.

Measure

SUBMITTER: Nanna MG 

PROVIDER: S-EPMC7280419 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature