Marriage of black phosphorus and Cu²⁺ as effective photothermal agents for PET-guided combination cancer therapy.

ABSTRACT: The use of photothermal agents (PTAs) in cancer photothermal therapy (PTT) has shown promising results in clinical studies. The rapid degradation of PTAs may address safety concerns but usually limits the photothermal stability required for efficacious treatment. Conversely, PTAs with high photothermal stability usually degrade slowly. The solutions that address the balance between the high photothermal stability and rapid degradation of PTAs are rare. Here, we report that the inherent Cu²⁺-capturing ability of black phosphorus (BP) can accelerate the degradation of BP, while also enhancing photothermal stability. The incorporation of Cu²⁺ into BP@Cu nanostructures further enables chemodynamic therapy (CDT)-enhanced PTT. Moreover, by employing ⁶⁴Cu^2+</

SUBMITTER: Hu K 

PROVIDER: S-EPMC7280494 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature