Metabolic associated fatty liver disease increases coronavirus disease 2019 disease severity in nondiabetic patients.

ABSTRACT:

Background and aim

Coronavirus disease 2019 (COVID-19) has attracted increasing worldwide attention. While diabetes is known to aggravate COVID-19 severity, it is not known whether nondiabetic patients with metabolic dysfunction are also more prone to more severe disease. The association of metabolic associated fatty liver disease (MAFLD) with COVID-19 severity in nondiabetic patients was investigated here.

Methods

The study cohort comprised 65 patients with (i.e. cases) and 65 patients without MAFLD (i.e. controls). Each case was randomly matched with one control by sex (1:1) and age (±5 years). The association between the presence of MAFLD (as exposure) and COVID-19 severity (as the outcome) was assessed by binary logistic regression analysis.

Results

In nondiabetic

SUBMITTER: Gao F 

PROVIDER: S-EPMC7280625 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature