Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptor Deficiency Promotes the Ductular Reaction, Macrophage Accumulation, and Hepatic Fibrosis in the Abcb4^-/- Mouse.

ABSTRACT: The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL; TNFSF10) receptor (TR) is a pro-apoptotic receptor whose contribution to chronic cholestatic liver disease is unclear. Herein, we examined TRAIL receptor signaling in a mouse model of cholestatic liver injury. TRAIL receptor-deficient (Tnsf10 or Tr^-/-) mice were crossbred with ATP binding cassette subfamily B member 4-deficient (Abcb4^-/-, alias Mdr2^-/-) mice. Male and female wild-type, Tr^-/-, Mdr2^-/-, and Tr^-/-Mdr2^-/- mice were assessed for liver injury, fibrosis, and ductular reactive (DR) cells. Macrophage subsets were examined by high-dimensional mass cytometry (time-of-flight mass cytometry). Mdr2^-/- and Tr^-/-Mdr2^-/-

SUBMITTER: Krishnan A 

PROVIDER: S-EPMC7280758 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature