Whole-blood hypocoagulable profile correlates with a greater risk of death within 28 days in patients with severe sepsis.

ABSTRACT:

Background

Hypocoagulability and impaired platelet function have been associated with a high risk of death in sepsis. The aim of this cohort study was to determine whether sepsis-induced hypocoagulability and platelet dysfunction (assessed by ROTEM® and MULTIPLATE®, respectively) are increased in sepsis patients who died within 28 days after diagnosis compared with patients who died between 29 and 90 days after diagnosis.

Methods

Consecutive patients admitted to the intensive care unit of Padova University Hospital from March 2015 to March 2018 for severe sepsis were considered. We collected blood samples from all patients to determine ROTEM® and MULTIPLATE® parameters. Each enrolled patient underwent a 90-day follow-up and the mortality rate was recorded.

Results

Of

SUBMITTER: Boscolo A 

PROVIDER: S-EPMC7280891 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature