Genome-Wide Association Meta-Analysis of Single-Nucleotide Polymorphisms and Symptomatic Venous Thromboembolism during Therapy for Acute Lymphoblastic Leukemia and Lymphoma in Caucasian Children.

ABSTRACT: Symptomatic venous thromboembolism (VTE) occurs in five percent of children treated for acute lymphoblastic leukemia (ALL), but whether a genetic predisposition exists across different ALL treatment regimens has not been well studied.

Methods

We undertook a genome-wide association study (GWAS) meta-analysis for VTE in consecutively treated children in the Nordic/Baltic acute lymphoblastic leukemia 2008 (ALL2008) cohort and the Australian Evaluation of Risk of ALL Treatment-Related Side-Effects (ERASE) cohort. A total of 92 cases and 1481 controls of European ancestry were included.

Results

No SNPs reached genome-wide significance (p < 5 × 10^-8) in either cohort. Among the top 34 single-nucleotide polymorphisms (SNPs) (p < 1 × 10^-6), two loc

SUBMITTER: Mateos MK 

PROVIDER: S-EPMC7280960 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature