Role of IL-17 gene polymorphisms in osteoarthritis: A meta-analysis based on observational studies.

ABSTRACT:

Background

Osteoarthritis (OA) is a chronic complex multifactorial joint disease, and a major degenerative form of arthritis. Existing studies on the association between polymorphisms of the IL-17 gene and the risk of OA in different populations have yielded conflicting findings.

Aim

To investigate the association between polymorphisms of the IL-17 gene and the risk of OA.

Methods

We conducted a meta-analysis by systematically searching databases, including PubMed, EMBASE, MEDLINE, Cochrane Library, and Google Scholar to evaluate this association by calculating pooled odds ratios with 95% confidence intervals. Moreover, subgroup analyses stratified by ethnicity and OA type were also conducted.

Results

In a total of 6 citations involving 8 studies

SUBMITTER: Yang HY 

PROVIDER: S-EPMC7281068 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature