Developmental Signatures of Microbiota-Derived Metabolites in the Mouse Brain.

ABSTRACT: The gut microbiome is recognized to exert a wide-ranging influence on host health and disease, including brain development and behavior. Commensal bacteria can produce bioactive molecules that enter the circulation and impact host physiology and homeostasis. However, little is known about the potential for these metabolites to cross the blood-brain barrier and enter the developing brain under normal physiological conditions. In this study, we used a liquid chromatography-mass spectrometry-based metabolomic approach to characterize the developmental profiles of microbial-derived metabolites in the forebrains of mice across three key postnatal developmental stages, co-occurring with the maturation of the gut microbiota. We demonstrate that direct metabolites of the gut microbiome (e.g., imid

SUBMITTER: Swann JR 

PROVIDER: S-EPMC7281085 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature