Cysteine Cathepsins Inhibition Affects Their Expression and Human Renal Cancer Cell Phenotype.

ABSTRACT: Renal cancer would greatly benefit from new therapeutic strategies since, in advanced stages, it is refractory to classical chemotherapeutic approaches. In this context, lysosomal protease cysteine cathepsins may represent new pharmacological targets. In renal cancer, they are characterized by a higher expression, and they were shown to play a role in its aggressiveness and spreading. Traditional studies in the field were focused on understanding the therapeutic potentialities of cysteine cathepsin inhibition, while the direct impact of such therapeutics on the expression of these enzymes was often overlooked. In this work, we engineered two fluoromethyl ketone-based peptides with inhibitory activity against cathepsins to evaluate their potential anticancer activity and impact on the lysos

SUBMITTER: Rudzinska M 

PROVIDER: S-EPMC7281206 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature