Trehalose Effect on the Aggregation of Model Proteins into Amyloid Fibrils.

ABSTRACT: Protein aggregation into amyloid fibrils is a phenomenon that attracts attention from a wide and composite part of the scientific community. Indeed, the presence of mature fibrils is associated with several neurodegenerative diseases, and in addition these supramolecular aggregates are considered promising self-assembling nanomaterials. In this framework, investigation on the effect of cosolutes on protein propensity to aggregate into fibrils is receiving growing interest, and new insights on this aspect might represent valuable steps towards comprehension of highly complex biological processes. In this work we studied the influence exerted by the osmolyte trehalose on fibrillation of two model proteins, that is, lysozyme and insulin, investigated during concomitant variation of the soluti

SUBMITTER: Mari E 

PROVIDER: S-EPMC7281244 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature