Detecting Endometrial Cancer by Blood Spectroscopy: A Diagnostic Cross-Sectional Study.

ABSTRACT: Endometrial cancer is the sixth most common cancer in women, with a rising incidence worldwide. Current approaches for the diagnosis and screening of endometrial cancer are invasive, expensive or of moderate diagnostic accuracy, limiting their clinical utility. There is a need for cost-effective and minimally invasive approaches to facilitate the early detection and timely management of endometrial cancer. We analysed blood plasma samples in a cross-sectional diagnostic accuracy study of women with endometrial cancer (n = 342), its precursor lesion atypical hyperplasia (n = 68) and healthy controls (n = 242, total n = 652) using attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy and machine learning algorithms. We show that blood-based infrared spectroscopy has

SUBMITTER: Paraskevaidi M 

PROVIDER: S-EPMC7281323 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature