Cytotoxic Scalarane Sesterterpenes from the Sponge Hyrtios erectus.

ABSTRACT: Twelve new sesterterpenes along with eight known sesterterpenes were isolated from the marine sponge Hyrtios erectus collected off the coast of Chuuk Island, the Federated State of Micronesia. Based upon a combination of spectroscopic and computational analyses, these compounds were determined to be eight glycine-bearing scalaranes (1-8), a 3-keto scalarane (9), two oxidized-furan-bearing scalaranes (10 and 11), and a salmahyrtisane (12). Several of these compounds exhibited weak antiproliferation against diverse cancer cell lines as well as moderate anti-angiogenesis activities. The antiproliferative activity of new compound 4 was found to be associated with G0/G1 arrest in the cell cycle.

SUBMITTER: Kwon OS 

PROVIDER: S-EPMC7281328 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature