Molecular and Clinical Relevance of ZBTB38 Expression Levels in Prostate Cancer.

ABSTRACT: Prostate cancer is one of the most commonly diagnosed cancers in men. A number of genomic and clinical studies have led to a better understanding of prostate cancer biology. Still, the care of patients as well as the prediction of disease aggressiveness, recurrence and outcome remain challenging. Here, we showed that expression of the gene ZBTB38 is associated with poor prognosis in localised prostate cancer and could help discriminate aggressive localised prostate tumours from those who can benefit only from observation. Analysis of different prostate cancer cohorts indicates that low expression levels of ZBTB38 associate with increased levels of chromosomal abnormalities and more aggressive pathological features, including higher rate of biochemical recurrence of the disease. Importantly

SUBMITTER: de Dieuleveult M 

PROVIDER: S-EPMC7281456 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature