Protein Supramolecular Structures: From Self-Assembly to Nanovaccine Design.

ABSTRACT: Life-inspired protein supramolecular assemblies have recently attracted considerable attention for the development of next-generation vaccines to fight against infectious diseases, as well as autoimmune diseases and cancer. Protein self-assembly enables atomic scale precision over the final architecture, with a remarkable diversity of structures and functionalities. Self-assembling protein nanovaccines are associated with numerous advantages, including biocompatibility, stability, molecular specificity and multivalency. Owing to their nanoscale size, proteinaceous nature, symmetrical organization and repetitive antigen display, protein assemblies closely mimic most invading pathogens, serving as danger signals for the immune system. Elucidating how the structural and physicochemical proper

SUBMITTER: Zottig X 

PROVIDER: S-EPMC7281494 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature