Emergence of Drift Variants That May Affect COVID-19 Vaccine Development and Antibody Treatment.

ABSTRACT: New coronavirus (SARS-CoV-2) treatments and vaccines are under development to combat COVID-19. Several approaches are being used by scientists for investigation, including (1) various small molecule approaches targeting RNA polymerase, 3C-like protease, and RNA endonuclease; and (2) exploration of antibodies obtained from convalescent plasma from patients who have recovered from COVID-19. The coronavirus genome is highly prone to mutations that lead to genetic drift and escape from immune recognition; thus, it is imperative that sub-strains with different mutations are also accounted for during vaccine development. As the disease has grown to become a pandemic, B-cell and T-cell epitopes predicted from SARS coronavirus have been reported. Using the epitope information along with variants o

SUBMITTER: Koyama T 

PROVIDER: S-EPMC7281497 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature