Effects of Beta-Blockers on Melanoma Microenvironment and Disease Survival in Human.

ABSTRACT: Background: The regulation of melanoma by noradrenergic signaling has gain attention since pre-clinical and clinical studies suggested a benefit of using beta-blockers to control disease progression. We need to confirm that human melanoma recapitulates the mechanisms described from pre-clinical models. Methods: The sources and targets of norepinephrine in the microenvironment of 20 human melanoma samples was investigated using immunostaining. The effect of an exposure to beta-blockers on immune cell type distribution and expression of immune response markers was assessed with immunostaining on 212 human primary melanoma. A statistical analysis explored the effect of an exposure to beta-blockers on progression free survival, melanoma related survival, and overall survival on the 286 eligibl

SUBMITTER: Wrobel LJ 

PROVIDER: S-EPMC7281512 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature