APC Mutation Marks an Aggressive Subtype of BRAF Mutant Colorectal Cancers.

ABSTRACT: WNT activation is a hallmark of colorectal cancer. BRAF mutation is present in 15% of colorectal cancers, and the role of mutations in WNT signaling regulators in this context is unclear. Here, we evaluate the mutational landscape of WNT signaling regulators in BRAF mutant cancers. we performed exome-sequencing on 24 BRAF mutant colorectal cancers and analyzed these data in combination with 175 publicly available BRAF mutant colorectal cancer exomes. We assessed the somatic mutational landscape of WNT signaling regulators, and performed hotspot and driver mutation analyses to identify potential drivers of WNT signaling. The effects of Apc and Braf mutation were modelled, in vivo, using the Apcmin/+ and BrafV637/Villin-CreERT2/+ mouse, respectively. RNF43 was the most frequently mutated WNT

SUBMITTER: Fennell LJ 

PROVIDER: S-EPMC7281581 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature