Clinical Implications of DNA Repair Defects in High-Grade Serous Ovarian Carcinomas.

ABSTRACT: Despite significant improvements in surgical and medical management, high grade serous ovarian cancer (HGSOC) still represents the deadliest gynecologic malignancy and the fifth most frequent cause of cancer-related mortality in women in the USA. Since DNA repair alterations are regarded as the "the Achille's heel" of HGSOC, both DNA homologous recombination and DNA mismatch repair deficiencies have been explored and targeted in epithelial ovarian cancers in the latest years. In this review, we aim at focusing on the therapeutic issues deriving from a faulty DNA repair machinery in epithelial ovarian cancers, starting from existing and well-established treatments and investigating new therapeutic approaches which could possibly improve ovarian cancer patients' survival outcomes in the near

SUBMITTER: Milanesio MC 

PROVIDER: S-EPMC7281678 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature