Adolescents at clinical high risk for psychosis show qualitatively altered patterns of activation during rule learning.

ABSTRACT:

Background

The ability to flexibly apply rules to novel situations is a critical aspect of adaptive human behavior. While executive function deficits are known to appear early in the course of psychosis, it is unclear which specific facets are affected. Identifying whether rule learning is impacted at the early stages of psychosis is necessary for truly understanding the etiology of psychosis and may be critical for designing novel treatments. Therefore, we examined rule learning in healthy adolescents and those meeting criteria for clinical high risk (CHR) for psychosis.

Methods

24 control and 22 CHR adolescents underwent rapid, high-resolution fMRI while performing a paradigm which required them to apply novel or practiced task rules.

Results

Previous work has sugge

SUBMITTER: Orr JM 

PROVIDER: S-EPMC7281799 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature