NLRP1 inflammasome contributes to chronic stress-induced depressive-like behaviors in mice.

ABSTRACT:

Background

Major depressive disorder (MDD) is a highly prevalent psychiatric disorder, and inflammation has been considered crucial components of the pathogenesis of depression. NLRP1 inflammasome-driven inflammatory response is believed to participate in many neurological disorders. However, it is unclear whether NLRP1 inflammasome is implicated in the development of depression.

Methods

Animal models of depression were established by four different chronic stress stimuli including chronic unpredictable mild stress (CUMS), chronic restrain stress (CRS), chronic social defeat stress (CSDS), and repeat social defeat stress (RSDS). Depressive-like behaviors were determined by sucrose preference test (SPT), forced swim test (FST), tail-suspension test (TST), open-field test (OFT

SUBMITTER: Song AQ 

PROVIDER: S-EPMC7281929 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature