Rosuvastatin protects against endothelial cell apoptosis in vitro and alleviates atherosclerosis in ApoE^-/- mice by suppressing endoplasmic reticulum stress.

ABSTRACT: The development of abnormal lipid-induced atherosclerosis is initiated with endothelial cell apoptosis. Vascular endothelial cells possess highly developed endoplasmic reticulum (ER), which is involved in lipid metabolism, indicating that ER stress may contribute chiefly to the induction of endothelial cell apoptosis. Based on its ability to reduce cholesterol levels, rosuvastatin may play an endothelial and vascular protective role by regulating ER stress. In the present study, the involvement of the inhibition of the ER stress-induced endothelial injury was investigated in combination with the lipid lowering effects of rosuvastatin. This compound can be used to inhibit cholesterol synthesis in atherosclerosis. Rosuvastatin decreased the apoptotic rates of human umbilical vascular endothe

SUBMITTER: Geng J 

PROVIDER: S-EPMC7282009 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature