Salmonella enterica serovar Typhimurium sseK3 induces apoptosis and enhances glycolysis in macrophages.

ABSTRACT:

Background

Salmonella enterica serovar Typhimurium (S. Typhimurium) is an important infectious disease pathogen that can survive and replicate in macrophages. Glycolysis is essential for immune responses against S. Typhimurium infection in macrophages, and is also associated with apoptosis. S. Typhimurium secreted effector K3 (SseK3) was recently identified as a novel translated and secreted protein. However, there is no study about the role of sseK3 in the relationship between apoptosis and glycolysis in cells infected with S. Typhimurium. It is unclear whether this protein exerts a significant role in the progress of apoptosis and glycolysis in S. Typhimurium-infected macrophages.

Results

Macrophages were infected with S. Typhimurium SL1344 wild-type (WT), ΔsseK3 mutant or

SUBMITTER: Yu C 

PROVIDER: S-EPMC7282050 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature