The correlation between imaging expression of P16 and S100 in hypertrophic ligamentum flavum.

ABSTRACT:

Background

Lumbar spinal stenosis (LSS) is a common degenerative disease, which can lead to neurological dysfunction and requires surgical treatment. In the previous study, we used H&E staining and immunohistochemistry to qualitatively analyze the expression of S100 and P16 in the pathological process of ligamentum flavum (LF) hypertrophy in patients with LSS. To further explore the relationship between P16, S100 and LF hypertrophy in patients with LSS, we quantitatively detected S100 and P16 and their expressed products based on molecular biology techniques, and analyzed their imaging correlation.

Methods

Before posterior lumbar surgery, LF thickness was measured by Magnetic Resonance Imaging (MRI). Through the operation, we obtained the specimens of LF from 120 patients, a

SUBMITTER: Hu W 

PROVIDER: S-EPMC7282051 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature