Human follicular fluid proteome reveals association between overweight status and oocyte maturation abnormality.

ABSTRACT:

Background

Human follicular fluid (HFF), which is composed by essential proteins required for the follicle development, provides an important microenvironment for oocyte maturation. Recently, overweight status has been considered as a detrimental impact factor on oocyte maturation, but whether HFF proteome could provide protein markers for assessing overweight-based oocyte maturation deficiency is still unknown.

Methods

To reveal the HFF-based molecular characteristics associated with abnormal oocyte maturation, an iTRAQ-based comparative proteomic analysis was performed to investigate different HFF protein expression profiles from normal weight women and overweight status women.

Results

Two hundred HFF proteins were quantified in our data, of which 43% have not been

SUBMITTER: Liu X 

PROVIDER: S-EPMC7282111 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature