Anti-malarial activity of traditional Kampo medicine Coptis rhizome extract and its major active compounds.

ABSTRACT:

Background

Herbal medicine has been a rich source of new drugs exemplified by quinine and artemisinin. In this study, a variety of Japanese traditional herbal medicine ('Kampo') were examined for their potential anti-malarial activities.

Methods

A comprehensive screening methods were designed to identify novel anti-malarial drugs from a library of Kampo herbal extracts (n = 120) and related compounds (n = 96). The anti-malarial activity was initially evaluated in vitro against chloroquine/mefloquine-sensitive (3D7) and-resistant (Dd2) strains of Plasmodium falciparum. The cytotoxicity was also evaluated using primary adult mouse brain cells. After being selected through the first in vitro assay, positive extracts and compounds were examined for possible in vivo anti-malarial

SUBMITTER: Teklemichael AA 

PROVIDER: S-EPMC7282140 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature