Restoration of antitumor immunity through anti-MICA antibodies elicited with a chimeric protein.

ABSTRACT:

Background

Natural killer and cytotoxic CD8⁺ T cells are major players during antitumor immunity. They express NKG2D, an activating receptor that promotes tumor elimination through recognition of the MHC class I chain-related proteins A and B (MICA and MICB). Both molecules are overexpressed on a great variety of tumors from different tissues, making them attractive targets for immunotherapy. However, tumors shed MICA and MICB, and the soluble forms of both (sMICA and sMICB) mediate tumor-immune escape. Some reports indicate that anti-MICA antibodies (Ab) can promote the restoration of antitumor immunity through the induction of direct antitumor effects (antibody-dependent cell-mediated cytotoxicity, ADCC) and scavenging of sMICA. Therefore, we reasoned that an active in

SUBMITTER: Torres N 

PROVIDER: S-EPMC7282397 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature