Using Kisspeptin to Predict Pubertal Outcomes for Youth With Pubertal Delay.

ABSTRACT:

Context

The management of youth with delayed puberty is hampered by difficulty in predicting who will eventually progress through puberty and who will fail to attain adult reproductive endocrine function. The neuropeptide kisspeptin, which stimulates gonadotropin-releasing hormone (GnRH) release, can be used to probe the integrity of the reproductive endocrine axis.

Objective

We sought to determine whether responses to kisspeptin can predict outcomes for individuals with pubertal delay.

Design, setting, and participants

We conducted a longitudinal cohort study in an academic medical center of 16 children (3 girls and 13 boys) with delayed or stalled puberty.

Intervention and outcome measures

Children who had undergone kisspeptin- and GnRH-stimulation tests were

SUBMITTER: Chan YM 

PROVIDER: S-EPMC7282711 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature