The utility of magnetic resonance imaging for noninvasive evaluation of diabetic nephropathy.

ABSTRACT:

Background

Noninvasive quantitative measurement of fibrosis in chronic kidney disease (CKD) would be desirable diagnostically and therapeutically but standard radiologic imaging is too variable for clinical usage. By applying a vibratory force, tissue shear wave stiffness can be measured by magnetic resonance elastography (MRE) that may correlate with progression of kidney fibrosis. Since decreased kidney perfusion decreases tissue turgor and stiffness, we combined newly available three-dimensional MRE shear stiffness measurements with MR arterial spin labeling (ASL) kidney blood flow rates to evaluate fibrosis in diabetic nephropathy.

Methods

Thirty individuals with diabetes and Stage 0-5 CKD and 13 control individuals without CKD underwent noncontrast MRE with concurrent A

SUBMITTER: Brown RS 

PROVIDER: S-EPMC7282829 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature