Expression of 22 serotonin-related genes in rat brain after sub-acute serotonin depletion or reuptake inhibition.

ABSTRACT: OBJECTIVE:Although the assessment of expression of serotonin-related genes in experimental animals has become a common strategy to shed light on variations in brain serotonergic function, it remains largely unknown to what extent the manipulation of serotonin levels causes detectable changes in gene expression. We therefore chose to investigate how sub-acute depletion or elevation of brain serotonin influences the expression of a number of serotonin-related genes in six brain areas. METHODS:Male Wistar rats were administered a serotonin synthesis inhibitor, para-chlorophenylalanine (p-CPA), or a serotonin reuptake inhibitor, paroxetine, for 3 days and then sacrificed. The expression of a number of serotonin-related genes in the raphe nuclei, hypothalamus, amygdala, striatum, hippocampus an

SUBMITTER: Naslund J 

PROVIDER: S-EPMC7282867 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature