Developmental programming of mitochondrial biology: a conceptual framework and review.

ABSTRACT: Research on mechanisms underlying the phenomenon of developmental programming of health and disease has focused primarily on processes that are specific to cell types, organs and phenotypes of interest. However, the observation that exposure to suboptimal or adverse developmental conditions concomitantly influences a broad range of phenotypes suggests that these exposures may additionally exert effects through cellular mechanisms that are common, or shared, across these different cell and tissue types. It is in this context that we focus on cellular bioenergetics and propose that mitochondria, bioenergetic and signalling organelles, may represent a key cellular target underlying developmental programming. In this review, we discuss empirical findings in animals and humans that sugge

SUBMITTER: Gyllenhammer LE 

PROVIDER: S-EPMC7282904 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature