Brain-age in midlife is associated with accelerated biological aging and cognitive decline in a longitudinal birth cohort.

ABSTRACT: An individual's brainAGE is the difference between chronological age and age predicted from machine-learning models of brain-imaging data. BrainAGE has been proposed as a biomarker of age-related deterioration of the brain. Having an older brainAGE has been linked to Alzheimer's, dementia, and mortality. However, these findings are largely based on cross-sectional associations which can confuse age differences with cohort differences. To illuminate the validity of brainAGE as a biomarker of accelerated brain aging, a study is needed of a large cohort all born in the same year who nevertheless vary on brainAGE. In the Dunedin Study, a population-representative 1972-73 birth cohort, we measured brainAGE at age 45 years, as well as the pace of biological aging and cognitive decline in longitu

SUBMITTER: Elliott ML 

PROVIDER: S-EPMC7282987 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature