Consensus recommendations for a standardized brain tumor imaging protocol for clinical trials in brain metastases.

ABSTRACT: A recent meeting was held on March 22, 2019, among the FDA, clinical scientists, pharmaceutical and biotech companies, clinical trials cooperative groups, and patient advocacy groups to discuss challenges and potential solutions for increasing development of therapeutics for central nervous system metastases. A key issue identified at this meeting was the need for consistent tumor measurement for reliable tumor response assessment, including the first step of standardized image acquisition with an MRI protocol that could be implemented in multicenter studies aimed at testing new therapeutics. This document builds upon previous consensus recommendations for a standardized brain tumor imaging protocol (BTIP) in high-grade gliomas and defines a protocol for brain metastases (BTIP-BM) that add

SUBMITTER: Kaufmann TJ 

PROVIDER: S-EPMC7283031 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature