Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIEN.

ABSTRACT:

Objective

We tested the hypothesis that exercise training would attenuate metabolic impairment in a model of severe cancer cachexia.

Methods

We used multiple in vivo and in vitro methods to explore the mechanisms underlying the beneficial effects induced by exercise training in tumor-bearing rats.

Results

Exercise training improved running capacity, prolonged lifespan, reduced oxidative stress, and normalized muscle mass and contractile function in tumor-bearing rats. An unbiased proteomic screening revealed COP9 signalosome complex subunit 2 (COPS2) as one of the most downregulated proteins in skeletal muscle at the early stage of cancer cachexia. Exercise training normalized muscle COPS2 protein expression in tumor-bearing rats and mice. Lung cancer patients with lo

SUBMITTER: Alves CRR 

PROVIDER: S-EPMC7283151 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature