Nox4 - RyR1 - Nox2: Regulators of micro-domain signaling in skeletal muscle.

ABSTRACT: The ability for skeletal muscle to perform optimally can be affected by the regulation of Ca²⁺ within the triadic junctional space at rest. Reactive oxygen species impact muscle performance due to changes in oxidative stress, damage and redox regulation of signaling cascades. The interplay between ROS and Ca²⁺ signaling at the triad of skeletal muscle is therefore important to understand as it can impact the performance of healthy and diseased muscle. Here, we aimed to examine how changes in Ca²⁺ and redox signaling within the junctional space micro-domain of the mouse skeletal muscle fibre alters the homeostasis of these complexes. The dystrophic mdx mouse model displays increased RyR1 Ca²⁺ leak and increased NAD(P)H Oxidase 2 ROS. These alterat

SUBMITTER: Cully TR 

PROVIDER: S-EPMC7283154 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature