Lung Function and Gene Expression of Pathogen Recognition Pathway Receptors: the Cardia Lung Study.

ABSTRACT: Activation of toll-like receptors (TLR1, TLR5, TLR6) and downstream markers (CCR1, MAPK14, ICAM1) leads to increased systemic inflammation. Our objective was to study the association between the gene expression levels of these six genes and lung function (Forced Expiratory Volume in one second (FEV₁), Forced Vital Capacity (FVC) and FEV₁/FVC). We studied gene expression levels and lung function in the Coronary Artery Risk Development in Young Adults study. Spirometry testing was used to measure lung function and gene expression levels were measured using the Nanostring platform. Multivariate linear regression models were used to study the association between lung function measured at year 30, 10-year decline from year 20 to year 30, and gene expression levels (highest

SUBMITTER: Ramasubramanian R 

PROVIDER: S-EPMC7283270 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature