Selection of the optimal intensity normalization region for FDG-PET studies of normal aging and Alzheimer's disease.

ABSTRACT: The primary method for measuring brain metabolism in humans is positron emission tomography (PET) imaging using the tracer ¹⁸F-fluorodeoxyglucose (FDG). Standardized uptake value ratios (SUVR) are commonly calculated from FDG-PET images to examine intra- and inter-subject effects. Various reference regions are used in the literature of FDG-PET studies of normal aging, making comparison between studies difficult. Our primary objective was to determine the optimal SUVR reference region in the context of healthy aging, using partial volume effect (PVE) and non-PVE corrected data. We calculated quantitative cerebral metabolic rates of glucose (CMRg) from PVE-corrected and non-corrected images from young and older adults. We also investigated regional atrophy using magnetic resonance

SUBMITTER: Nugent S 

PROVIDER: S-EPMC7283334 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature