Combining measures of immune infiltration shows additive effect on survival prediction in high-grade serous ovarian carcinoma.

ABSTRACT:

Background

In colorectal and breast cancer, the density and localisation of immune infiltrates provides strong prognostic information. We asked whether similar automated quantitation and combined analysis of immune infiltrates could refine prognostic information in high-grade serous ovarian carcinoma (HGSOC) and tested associations between patterns of immune response and genomic driver alterations.

Methods

Epithelium and stroma were semi-automatically segmented and the infiltration of CD45RO⁺, CD8⁺ and CD68⁺ cells was automatically quantified from images of 332 HGSOC patient tissue microarray cores.

Results

Epithelial CD8 [p = 0.027, hazard ratio (HR) = 0.83], stromal CD68 (p = 3 × 10^-4, HR = 0.44) and stromal CD45RO (p = 7 

SUBMITTER: Montfort A 

PROVIDER: S-EPMC7283353 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature