The Local and Peripheral Immune Responses to Stroke: Implications for Therapeutic Development.

ABSTRACT: The immune response to stroke is an exciting target for future stroke therapies. Stroke is a leading cause of morbidity and mortality worldwide, and clot removal (mechanical or pharmacological) to achieve tissue reperfusion is the only therapy currently approved for patient use. Due to a short therapeutic window and incomplete effectiveness, however, many patients are left with infarcted tissue that stimulates inflammation. Although this is critical to promote repair, it can also damage surrounding healthy brain tissue. In addition, acute immunodepression and subsequent infections are common and are associated with worse patient outcomes. Thus, the acute immune response is a major focus of researchers attempting to identify ways to amplify its benefits and suppress its negative effects to

SUBMITTER: Zera KA 

PROVIDER: S-EPMC7283378 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature