Ontology highlight
ABSTRACT:
SUBMITTER: Zhao J
PROVIDER: S-EPMC7283397 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Zhao Junli J Zheng Yang Y Liu Keyue K Chen Junzi J Lai Nanxi N Fei Fan F Shi Jiaying J Xu Cenglin C Wang Shuang S Nishibori Masahiro M Wang Yi Y Chen Zhong Z
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20200401 2
Status epilepticus (SE), a life-threatening neurologic emergency, is often poorly controlled by the current pharmacological therapeutics, which are limited to a narrow time window. Here, we investigated the proinflammatory cytokine high mobility group box-1 (HMGB1) as a candidate therapeutic target for diazepam (DZP)-refractory SE. We found that HMGB1 was upregulated and translocated rapidly during refractory SE period. Exogenous HMGB1 was sufficient to directly induce DZP-refractory SE in nonre ...[more]