Dataset Information

Galantamine Inhibits Aβ_1-42-Induced Neurotoxicity by Enhancing α7nAChR Expression as a Cargo Carrier for LC3 Binding and Aβ_1-42 Engulfment During Autophagic Degradation.

ABSTRACT: Despite Alzheimer's disease (AD) being the most common neurodegenerative disorder worldwide, no FDA-approved disease-modifying treatments have been approved for this condition since 2003. Neuronal-type alpha7 nicotinic acetylcholine receptors (α7nAChRs) play an essential role in cognitive functions, binding with extracellular β-amyloid (Aβ plaques) and inhibiting Aβ-induced neurotoxicity. α7nAChRs are impaired early in the course of AD; drugs targeting α7nAChRs are being hotly pursued as a treatment of AD. Encenicline, a partial selective agonist of α7nAChR and modulator of acetylcholine, failed in phase III trials because of gastrointestinal side effects. We, therefore, evaluated the efficacy of galantamine, a positive allosteric modulator at α7nAChRs and an acetylcholinesterase inhibitor

SUBMITTER: Lin MW

PROVIDER: S-EPMC7283419 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Dataset Information

Galantamine Inhibits Aβ_1-42-Induced Neurotoxicity by Enhancing α7nAChR Expression as a Cargo Carrier for LC3 Binding and Aβ_1-42 Engulfment During Autophagic Degradation.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Galantamine Inhibits Aβ1-42-Induced Neurotoxicity by Enhancing α7nAChR Expression as a Cargo Carrier for LC3 Binding and Aβ1-42 Engulfment During Autophagic Degradation.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Galantamine Inhibits Aβ_1-42-Induced Neurotoxicity by Enhancing α7nAChR Expression as a Cargo Carrier for LC3 Binding and Aβ_1-42 Engulfment During Autophagic Degradation.