Ontology highlight
ABSTRACT:
SUBMITTER: Song D
PROVIDER: S-EPMC7283476 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Nature communications 20200609 1
The hippocampal CA3 contributes to spatial working memory (SWM), but which stage of SWM the CA3 neurons act on and whether the lateralization of CA3 function occurs in SWM is also unknown. Here, we reveal increased neural activity in both sample and choice phases of SWM. Left CA3 (LCA3) neurons show higher sensitivity in the choice phase during the correct versus error trials compared with right CA3 (RCA3) neurons. LCA3 initiates firing prior to RCA3 in the choice phase. Optogenetic suppression ...[more]