MicroRNA-95-3p inhibits cell proliferation and metastasis in colorectal carcinoma by HDGF.

ABSTRACT:

Background

MicroRNAs (miRNAs) play an important regulatory role in carcinogenesis and cancer progression. MiR-95-3p has been reported to be an oncogene in hepatocellular carcinoma. However, the role of miR-95-3p in colorectal carcinoma (CRC) remains unclear.

Methods

miR-95-3p was validated in an independent validation sample cohort of 215 CRC tissues. Functional assays, Cell proliferation (MTT) assay colony formation, wound healing, transwell and animal xenograft assays were used to determine the oppressor role of miR-95-3p in human CRC progression. Furthermore, Bioinformatics analysis, western blotting and dual-luciferase reporter assay were used to determine the mechanism by which miR-95-3p suppresses progression of CRC cells.

Results

In this study, we found that mi

SUBMITTER: Hong YG 

PROVIDER: S-EPMC7283574 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature