Two Tandem Mechanisms Control Bimodal Expression of the Flagellar Genes in Salmonella enterica.

ABSTRACT: Flagellar gene expression is bimodal in Salmonella enterica Under certain growth conditions, some cells express the flagellar genes whereas others do not. This results in mixed populations of motile and nonmotile cells. In the present study, we found that two independent mechanisms control bimodal expression of the flagellar genes. One was previously found to result from a double negative-feedback loop involving the flagellar regulators RflP and FliZ. This feedback loop governs bimodal expression of class 2 genes. In this work, a second mechanism was found to govern bimodal expression of class 3 genes. In particular, class 3 gene expression is still bimodal, even when class 2 gene expression is not. Using a combination of experimental and modeling approaches, we found that class 3 bimodali

SUBMITTER: Wang X 

PROVIDER: S-EPMC7283601 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature