Analysis of TCR Repertoire and PD-1 Expression in Decidual and Peripheral CD8⁺ T Cells Reveals Distinct Immune Mechanisms in Miscarriage and Preeclampsia.

ABSTRACT: CD8⁺ T cells, the most abundant T cell subset in the decidua, play a critical role in the maintenance of pregnancy. The majority of decidual CD8⁺ T cells have an effector memory phenotype, while those in the peripheral blood display a naive phenotype. An increased amount of highly differentiated CD8⁺ T cells in the decidua indicates local antigen stimulation and expansion, albeit these CD8⁺ T cells are suppressed. In decidual CD8⁺ T cells, co-inhibitory molecules such as PD-1, TIM-3, LAG-3, and CTLA-4 are upregulated, reflecting the suppression of cytotoxicity. Previous studies established the importance of the PD-1/PD-L1 interaction for feto-maternal tolerance. CD8⁺ T cells could directly recognize fetal-specific antigens,

SUBMITTER: Morita K 

PROVIDER: S-EPMC7283903 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature