Genetic polymorphisms of IL1RN were associated with lumbar disk herniation risk in a Chinese Han population.

ABSTRACT:

Background

Interleukin (IL)-1 is a cytokine superfamily, which involved in the inflammatory process and immune response in human body. IL-1 receptor antagonist (IL1RN) has been found to be associated with risk of lumbar disk herniation (LDH) in Finland samples. However, to date, there was no investigation focus on the polymorphisms of IL1RN in Chinese Han LDH patient.

Materials and methods

We conducted a case-control study based on 498 LDH patients and 463 controls. Five single-nucleotide polymorphisms (SNPs) in IL1RN were genotyped.

Results

As a result, we found that the AG and GG genotypes of rs3181052 were associated with decreased risk LDH under the dominant model (OR = 0.74, 95%CI: 0.57-0.96, p = .025). In the stratification analysis, the frequency of the "A" all

SUBMITTER: Tai A 

PROVIDER: S-EPMC7284030 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature