Bioinformatics analysis and verification of gene targets for benign tracheal stenosis.

ABSTRACT:

Background

Tracheal injury could cause intratracheal scar hyperplasia which in turn causes benign tracheal stenosis (TS). With the increasing use of mechanical ventilation and ventilator, the incidence of TS is increasing. However, the molecular mechanisms of TS have not been elucidated. It is significant to further explore the molecular mechanisms of TS.

Methods

The repeatability of public data was verified. Differently expressed genes (DEGs) and most significant genes were identified between TS and normal samples. Enrichment analysis of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were analyzed. The comparative toxicogenomics database were analyzed. TS patients were recruited and RT-qPCR were performed to verify the most significant genes.

Resul

SUBMITTER: Li XZ 

PROVIDER: S-EPMC7284051 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature